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Ph-Ph+

CAS No. :

MCE 站：Ph-Ph+

产品活性：Ph-Ph+ 是一种半质子型化合物，由菲咯啉 (ph) 二聚化产生。Ph-Ph+ 具有抗肿瘤、抗菌和抗真菌活性。

研究领域：Anti-infection  |  Apoptosis

作用靶点：Bacterial  |  Fungal  |  Apoptosis

In Vitro: Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) inhibits the various tumor cell proliferation in a concentration- ａnd time-dependent manner for H22, U251MG, human neuroblastoma SH-SY5Y cell line, mouse melanoma B16 cell line, ａnd human lung adenocarcinoma A549 cell line). , Ph-Ph+ does not affect the viabilities of human L02 cells ａnd HUVEC cells. Under an optical microscope, Ph-Ph+-treated tumor cells shrank ａnd exhibited apoptotic bodies. Ph-Ph+ has a selective antitumor effect through inducing cell apoptosis.
Ph-Ph+ has broad-spectrum antibacterial ａnd antifungal activities, ａnd drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus.

In Vivo: The tumor-bearing mice were prepared using the subcutaneous transplantation mouse hepatoma H22 cell line. Ph-Ph+ (2-8 mg/kg; i.v; for 8 days) treatment reduces tumor volume ａnd weight in a dose-dependent manner.
In animal models of liver cancer with fungal infection, the Ph-Ph+ (2-8 mg/kg; i.v; once a day for 9 days) retards proliferation of hepatoma cells in tumor-bearing mice ａnd remedies pneumonia ａnd encephalitis caused by Cryptococcus neoformans.

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