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Topoisomerase I/II inhibitor 2

CAS No. :

MCE 站：Topoisomerase I/II inhibitor 2

产品活性：Topoisomerase I/II inhibitor 2 (compound 1a) 是一种有效的拓扑异构酶 (Topoisomerase) 抑制剂，Huh7 与 LM9 细胞中的 IC₅₀ 分别为 9.82 μM 和 6.83 μM。Topoisomerase I/II inhibitor 2 对 DNA 拓扑异构酶 I/II 具有双重抑制，也能抑制小鼠模型中的异种移植肿瘤。Topoisomerase I/II inhibitor 2 具有治疗肝癌的潜在价值。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: Topoisomerase I/II inhibitor 2 (compound 1a) (0-150 μM; 72 hours) has favourable anti-proliferative activity in cancer cell lines, ａnd better inhibitory activity on two human hepatocellular carcinoma cell lines (HuH7, LM9).
Topoisomerase I/II inhibitor 2 (20 μM; 24 hours) has no damage to the DNA of HuH7 cells while some damage is noticed on LM9 cells.
Topoisomerase I/II inhibitor 2 (1.25-8 μM; 1-2 weeks) inhibits cell proliferation of LM9 ａnd Huh7 in a concentration-dependent manner.
Topoisomerase I/II inhibitor 2 (1.25-8 μM; 24 hours) has a good inhibitory effect on the migration ａnd invasion of LM9 ａnd HuH7 cells with concentration-dependent manner.
Topoisomerase I/II inhibitor 2 (0-20 μM; 24 hours) can inhibit the expression of matrix metalloproteinases-9 (MMP-9) in LM9 ａnd HuH7 cells.
Topoisomerase I/II inhibitor 2 (0-20 μM; 48 hours) inhibits cells proliferation by blocking cell cycle at the G₂/M phase.
Topoisomerase I/II inhibitor 2(3.5-20 μM; 48 hours) can injure mitochondrial function ａnd induce cell apoptosis in a concentration-dependent manner.

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