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FtsZ-IN-1

CAS No. : 2516246-24-3

MCE 站：FtsZ-IN-1

产品活性：FtsZ-IN-1 是一种具有喹啉环的有效的 FtsZ 抑制剂。FtsZ-IN-1 对革兰氏阳性菌具有较强的抑菌活性，MIC 为 0.5 - 8 μg/mL。FtsZ-IN-1 通过增强 FtsZ 聚合作用，显著促进枯草芽孢杆菌 (B. subtilis) 的细胞伸长。FtsZ-IN-1 具有低溶血毒性和低诱导耐药倾向，具有抗耐药性细菌活性。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: FtsZ-IN-1 (compound A3) inhibits effectively the growth of S. aureus with MICs of 0.5-1 μg/mL, ａnd generally displays less antibacterial potency against most Gram-negative bacteria tested such as E. coli ATCC 8739 (MIC = 64 μg/mL) ａnd P. Aeruginosa ATCC 27853 (MIC >64 μg/mL).
FtsZ-IN-1 exhibits MBCs of 4-8 μg/mL ａnd MICs of 1-4 μg/mL against S. aureus, B. subtilis ａnd E. faecium.
FtsZ-IN-1 (0-24 μg/mL; 24 hours) inhibits the growth of S. aureus in a bacteriostatic mode at 1×, 2×, 4× MIC concentrations, ａnd kills S. aureus at 8× MIC concentration.
FtsZ-IN-1 can restore the antibacterial activity of methicillin against MRSA in a synergistic manner, with MIC of 2 μg/mL.
FtsZ-IN-1 (2 μg/mL; 4 hours) can enlarge cell size of B. subtilis ａnd inhibits bacterial cell division.
FtsZ-IN-1 (0-15 μg/mL; 48 hours) exhibits IC₅₀s of 12.77 ａnd 9.42 μg/mL in L929 ａnd HK-2 cells.
FtsZ-IN-1 (2 μg/mL) can effectively delay the induction of drug resistance.
In a Hemolytic activity assay, FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC₅ of 64 μg/mL.

In Vivo: FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC₅ of 64 μg/mL.

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