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Tubulin inhibitor 25

CAS No. : 2411697-71-5

MCE 站：Tubulin inhibitor 25

产品活性：Tubulin inhibitor 25 是一种有效的微管蛋白 (tubulin) 抑制剂，IC₅₀ 为 0.98 μM。Tubulin inhibitor 25 对 HT29 细胞有显著的抑制作用。Tubulin inhibitor 25 能抑制细胞迁移和微管形成，有助于抗血管生成。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Microtubule/Tubulin

In Vitro: Tubulin inhibitor 25 (compound 6c) (0-100 μM; 48 hours) exhibits high antiproliferative activity against tested cancer cell lines.
Tubulin inhibitor 25 (0-200 μM; 48 hours) exhibits low cytotoxicity in normal cell lines.
Tubulin inhibitor 25 (0.05, 0.1 ａnd 0.2 μM; 24 hours) inhibits the colony formation of HT29 cells in a dose-dependent manner.
Tubulin inhibitor 25 (2 ａnd 4 μM) can inhibit the tubulin polymerization ａnd compete with colchicine binding site.
Tubulin inhibitor 25 (0.25-1 μM; 12-48 hours) arrests the cell cycle at G2/M phase ａnd induces HT29 cells apoptosis in a dose- ａnd time-dependent manner, besides induces HT29 cell depolarized mitochondria in the process of apoptosis.
Tubulin inhibitor 25 (0.25-1 μM; 24 hours) increases the expression of P21 ａnd Cyclin B1 ａnd decreases the expression of Cdc2, p-CDC2 ａnd p-Cdc25c; as well as induces the microtubule collapse in HT29 cells in a dose-dependent manner.
Tubulin inhibitor 25 (0.01, 0.02 ａnd 0.04 μM; 6 hours) effectively inhibits the HUVEC tube formation in a dose-dependent manner.
Tubulin inhibitor 25 (0.1, 0.2 ａnd 0.4 μM; 24 hours) inhibits migration of A549 cells in a dose-dependent manner.

In Vivo: Tubulin inhibitor 25 (1.5 mg/kg; IV; single) exhibits good metabolic stability.
Pharmacokinetic Parameters of Tubulin inhibitor 25 in male Sprague-Dawley rats.

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