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MAO-B-IN-7

CAS No. :

MCE 站：MAO-B-IN-7

产品活性：MAO-B-IN-7 是一种有效且具有血脑屏障渗透性的 MAO-B 和 AChE 抑制剂，对人 AChE、电鳗 AChE 和 MAO-B 的 IC₅₀ 分别为 41 nM、87 nM 和 0.3 μM。MAO-B-IN-7 能有效缓解氧化应激和神经炎症损伤。

研究领域：Neuronal Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：Monoamine Oxidase  |  AChE  |  ROS

In Vitro: MAO-B-IN-7 (compound 7d) can effectively interact with Cu²⁺ to form the corresponding complexes, ａnd has good ability to inhibit ROS’s production induced by Cu²⁺.
MAO-B-IN-7 (10-100 μM; 24 hours) decreases the viability of PC-12 cells at 100 μM, but does not show obvious cytotoxicity at 10 ａnd 25 μM.
MAO-B-IN-7 (4-25 μM; 24 hours) protects H₂O₂-induced PC-12 cells injury, ａnd the cell viability are 80.2%, 71.1% ａnd 56.3% at 25.0 μM, 10.0 μM ａnd 4.0 μM, respectively..
MAO-B-IN-7 (2.5 μM ａnd 10 μM; 8 ａnd 24 hours) inhibits ROS production induced by LPS in BV-2 cells in a dose-dependent manner; inhibits NO production with 30.4%, 43.5% ａnd 58.9% at the concentrations of 0.5 μM, 2.5 μM ａnd 10.0 μM, respectively; also inhibits TNF-α release with 32.7%, 47.8% ａnd 63.2% at the concentrations of μM, 2.5 μM ａnd 10.0 μM, respectively.
MAO-B-IN-7 exhibits the parallel artificial membrane permeation of 8.59 × 10^-6 in vitro blood-brain barrier permeation study.

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