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Malabaricone B

CAS No. : 63335-24-0

MCE 站：Malabaricone B

产品活性：Malabaricone B 是一种天然存在的植物酚类物质，是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂，IC₅₀ 为 63.7 M。Malabaricone B 具有抗癌、抗菌、抗氧化和抗糖尿病活性。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Glucosidase  |  Apoptosis

In Vitro: Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) ａnd T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) ａnd lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC₅₀ = 8.1 μM), which is significantly better than that of curcumin (IC₅₀ = 26.7 μM).
The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 ａnd 20 M) increases the BAX level while simultaneously decreasing the BCL-2 ａnd BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, ａnd the activation of caspase-9 ａnd caspase-3.
Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus ａnd Candida albicans.

In Vivo: Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice.

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