MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Chicoric acid

CAS No. : 6537-80-0

MCE 站：Chicoric acid

产品活性：Chicoric acid (Cichoric acid) 是一种口服有效的二咖啡基酒石酸，可以诱导活性氧 (ROS) 的产生。Chicoric acid 抑制细胞活力，并通过 ROS 介导的 PI3K/Akt 和 MAPK 信号通路诱导 3T3-L1 前脂肪细胞中的线粒体依赖性细胞凋亡。Chicoric acid 增加葡萄糖摄取，改善胰岛素抵抗，并减轻氨基葡萄糖诱导的炎症。Chicoric acid 具有抗糖尿病和抗氧化、抗炎作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Apoptosis

结构分类：酚类  |  多酚类  |  苯丙素类  |  其他苯丙素类

来源：植物  |  其他科

In Vitro: Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, ａnd 72 h) causes a dose- ａnd time-dependent decrease in cell viability.
Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway.
Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt.
Chicoric acid (25, 50, 100 M; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, ａnd Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells.
Chicoric acid (100 M; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells.
Chicoric acid (100 M) has no effects on HepG2 cell viability.

In Vivo: Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis ａnd adjusts islet function in diabetic mice, leading to an increase in insulin generation ａnd secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days).

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Mitochondria-Targeted Compound Library  |  Food-Sourced Compound Library   |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Y-27632 dihydrochloride  |  Paclitaxel  |  Acetylcysteine  |  Tamoxifen  |  Angiotensin II human  |  Staurosporine  |  Bortezomib  |  2-Deoxy-D-glucose  |  5-Fluorouracil  |  Sorafenib  |  H2DCFDA  |  SP600125  |  Trametinib  |  Temozolomide  |  Gemcitabine  |  MK-2206 dihydrochloride  |  Decitabine  |  Verteporfin  |  Gefitinib  |  Etoposide  |  CCCP  |  DAPT  |  Rote  |  Ruxolitinib  |  Mdivi-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。