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E3 Ligase Ligand Library

MCE 站：E3 Ligase Ligand Library

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker ａnd a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), ａnd mouse double minute 2 homolog (MDM2). MCE carefully prepared a unique collection of 42 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Description & Advantages:

   A unique collection of 42 ligands for E3 ligase, which can be used for PROTAC design.

   A useful tool for PROTAC development.

   Mainly target VHL, CRBN, IAPs ａnd MDM2.

   More detailed compound information with structure, IC50, ａnd brief introduction.

   High purity ａnd quality validated by NMR ａnd LC/MS.

   All compounds are in stock ａnd continuously updated.

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