型号:
产品价格:电议      采购度:1183      原产地:美洲
发布时间:2022/9/1 12:19:05 所属地区:国外 国外
简要描述:
Mycophenolic acid sodium 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂,EC50 为 M。Mycophenolic acid sodium 对多种 RNA 病毒具有抗病毒作用,包括流感 (influenza)。Mycophenolic acid sodium 是一种免疫抑制剂。具有抗血管生成和抗肿瘤作用。
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 37415-62-6
MCE 站:Mycophenolic acid sodium
产品活性:Mycophenolic acid sodium 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂,EC50 为 0.24 M。Mycophenolic acid sodium 对多种 RNA 病毒具有抗病毒作用,包括流感 (influenza)。Mycophenolic acid sodium 是一种免疫抑制剂。具有抗血管生成和抗肿瘤作用。
研究领域:Apoptosis | Anti-infection | Metabolic Enzyme/Protease
作用靶点:Apoptosis | Bacterial | Fungal | Antibiotic | Endogenous Metabolite
In Vitro: Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus.
IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides.
Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC50 <500 nM for antimitotic effects.
Fibroblasts are also prone to Mycophenolic acid-induced cell cycle inhibition but exhibit a higher IC50 (<1 μM) compared with endothelial cells. The two human tumor cell lines A549 non-small cell lung cancer cells and PC3 prostate cancer cells show intermediate sensitivity with an IC50 >1 μM. U87 glioblastoma cells are resistant against Mycophenolic acid sodium treatment up to 1 μM.
Mycophenolic acid (0.05-2 μM; 18 hours) sodium exhibits a dose-dependent down-regulation of HDAC2 and MYC, whereas up-regulates NDRG1.
In Vivo: Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodium exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice.
相关产品:MG-132 | Rapamycin | Ferrostatin-1 | 3-Methyladenine | LY294002 | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Y-27632 dihydrochloride | Paclitaxel | Puromycin dihydrochloride | Acetylcysteine | Tamoxifen | Dexamethasone | Deferoxamine mesylate | Cycloheximide | Angiotensin II human | Staurosporine | Bortezomib | 2-Deoxy-D-glucose | 5-Fluorouracil | Sorafenib | SP600125 | Trametinib | G-418 disulfate | Temozolomide | Gemcitabine | ATP | Retinoic acid
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 染料试剂 | PROTAC | 同位素标记物 | 寡核苷酸
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:26:02
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品