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NAAD sodium

CAS No. : 104809-30-5

MCE 站：NAAD sodium

产品活性：NAAD sodium (Deamido nad sodium) 是一种功能性 NAD⁺ 前体，是谷氨酰胺依赖性 NAD⁺ 合成酶的底物。NAAD sodium 用于研究烟酸单核苷酸腺苷酸转移酶的结构。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: In peripheral blood mononuclear cells (PBMC), NAAD sodium is only expected to be produced in biosynthesis of NAD⁺ from tryptophan ａnd NA2, was elevated from less than 20nM to as high as 0.91μM.
Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD).

In Vivo: In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340pmol/mg) in 15min. Hepatic NA appearance is followed by an expected peak of 220 NAAD sodium at 1h post gavage ａnd a rise in hepatic NAD⁺ from 990 baseline to 2200 at 2h.
NAAD sodium is reported in mouse liver when 500mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD sodium is observed in kidneys, ovaries, lung, heart ａnd brain in addition to liver in mice IP-injected with 500mg/kg of NA but not Nam.

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