MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Quinine hydrobromide

CAS No. : 549-49-5

MCE 站：Quinine hydrobromide

产品活性：Quinidine hydrobromide 是一种抗心律失常剂。Quinidine hydrobromide 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K⁺ 通道 (K⁺ channel) 的有效阻断剂，其 IC₅₀ 值为 19.9 μM。Quinidine hydrobromide 也可用作疟疾的研究。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease  |  Membrane Transporter/Ion Channel

作用靶点：Parasite  |  Cytochrome P450  |  Potassium Channel

In Vitro: Quinidine hydrobromide is an anti-arrythmic drug which affects ionic currents in heart muscle ａnd which has also been shown to be a potent blocker of several classes of K⁺ channel in a variety of cell types.
Bath application of quinidine hydrobromide causes a dose-dependent reduction of the peak amplitude of I_k. The K_d for blockade of I_k at 0 mV is estimated to be 41 μM.
Quinidine hydrobromide elicits a dose-dependent increase of the rate of the decay of I_k ａnd this effect is enhanced by membrane depolarization. Quinidine also causes a 5 mV hyperpolarizing shift of the steady-state inactivation curve ａnd increases the half-time for recovery from inactivation. Quinidine hydrobromide does not affect the onset of inactivation measured at -30 mV.

In Vivo: Quinidine hydrobromide is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose. Other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations.
Quinidine hydrobromide is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form ａnd 2＇-quinidi.
Quinidine hydrobromide inhibits metabolism of amphetamine in rats. Quinidine hydrobromide pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 ａnd 48 h to 7.2 ａnd 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 ａnd 48 h to 542% of the control.

相关产品：Chloroquine  |  Nigericin sodium salt  |  Yoda 1  |  BAPTA-AM  |  Hydroxychloroquine sulfate  |  Minocycline hydrochloride  |  Metronidazole  |  Dihydroartemisinin  |  Kaempferol  |  Apigenin  |  Branaplam  |  Ivermectin  |  Niclosamide  |  Artesunate  |  Fenofibrate  |  Ketoconazole  |  Verapamil  |  Chlorpromazine hydrochloride  |  Eflornithine hydrochloride hydrate  |  1-Aminobenzotriazole  |  Rosuvastatin Calcium  |  Artemisinin  |  Suramin sodium salt  |  Abiraterone  |  Quinidine  |  Halofugi  |  Itraconazole  |  Tetrandrine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。