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Pilocarpine

CAS No. : 92-13-7

MCE 站：Pilocarpine

产品活性：Pilocarpine 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: To evaluate the cytotoxicity of Pilocarpine, the morphology ａnd viability of human corneal stromal (HCS) cells are examined by light microscopy ａnd MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- ａnd time-dependent proliferation retardation ａnd morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, ａnd eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L ａnd controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time ａnd concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC₅₀ of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM).

In Vivo: The Pilocarpine-induced saliva secretion of the control rats (CN) ａnd exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na⁺ concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).

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