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Cimetidine hydrochloride

CAS No. : 70059-30-2

MCE 站：Cimetidine hydrochloride

产品活性：Cimetidine (SKF-92334) hydrochloride 是一种具有口服活性的，可逆的组胺 H2 受体拮抗剂，K_i 为 0.6 μM。Cimetidine hydrochloride 是一种胃酸减少剂，可用于十二指肠和胃溃疡研究。Cimetidine hydrochloride 具有抗癌和抗炎活性。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Cimetidine (SKF-92334) hydrochloride, a partial agonist for H2R, has a pharmacological profile different from ranitidine ａnd famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine hydrochloride has no effect on the uptake ａnd cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells).
Cimetidine hydrochloride shows no effect on proliferation, survival, migration ａnd invasion of 3LL cells. Cimetidine hydrochloride reverses MDSC-mediated T-cell suppression, ａnd improves IFN-γ production.
Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression.

In Vivo: Cimetidine (SKF-92334) hydrochloride reduces CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood ａnd tumor tissue of tumor-bearing mice.
Cimetidine hydrochloride exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue ａnd reducing alveolar bone resorption.

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