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Roxatidine acetate

CAS No. : 78628-28-1

MCE 站：Roxatidine acetate

产品活性：Roxatidine acetate 是一种有效的、选择性的、竞争性的、具有口服活性的组胺 H2 受体（histamine _H2-receptor）拮抗剂。Roxatidine acetate 对胃酸分泌有抗分泌作用。Roxatidine acetate 还能抑制炎症反应，可用于胃溃疡和十二指肠溃疡的研究。Roxatidine acetate 具有抗肿瘤活性。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Roxatidine acetate (0-120 μM, 1 h) suppresses inflammatory responses via inhibition of NF-κB ａnd p38 MAPK activation in LPS-induced RAW 264.7 macrophages.
Roxatidine acetate (6.25 μM, 12.5μM, ａnd 25μM; pre-treatment for 30min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, ａnd p38 MAPK levels are unaffected by roxatidine in human mast-cells-1 (HMC-1) cells.

In Vivo: Roxatidine acetate (0-300 mg/kg; p.o.; 26 days) suppressed growth of Colon 38 tumor implants in mice.
Roxatidine acetate (oral gavage; 20mg/kg; single dose) inhibits Compound 48/80-increased TNF-α, IL-6, ａnd IL-1β production ａnd mRNA expression. Additionally, Roxatidine decreases the compound 48/80-induced degradation of procaspase-1 ａnd appearance of the corresponding cleaved bands in mice.

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