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Mecamylamine

CAS No. : 60-40-2

MCE 站：Mecamylamine

产品活性：Mecamylamine 是一种具有口服活性，非选择性，非竞争性的 nAChR 拮抗剂。Mecamylamine 也是一种神经节阻滞剂，可穿过血脑屏障。Mecamylamine 可用于神经疾病，高血压，抗抑郁的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  GPCR/G Protein  |  Immunology/Inflammation

作用靶点：nAChR  |  Histamine Receptor

In Vitro: Mecamylamine (0.5-9 μM, bath administered) increases the firing frequency of identified 5-HT DRN neurons.
Mecamylamine (0.5-9 μM, bath administered) increases the glutamatergic ａnd decreases the GABAergic input of 5-HT DRN neurons.
Mecamylamine (1 mM, 5 min) blocks the histamine receptor ａnd the histamine-induced contractions in helically cut strips of rabbit aorta.
Mecamylamine (10 μM,48 h) attenuates the effect of nicotine’s action of neuroprotection.
Mecamylamine (1-100 nM, 30 min) dose-dependently attenuates endothelial tube formation in HDMVECs.

In Vivo: Mecamylamine (subcutaneous pumps, 50 mg/kg/day, 2 days) inhibits Choroidal neovascularization (CNV) in CNV mice model.
Mecamylamine (intraperitoneal injection, 0.5-1 mg/kg) has antidepressant-like effects in both the TST (tail suspension test) ａnd FST (forced swim test) in C57BL/6J mice, which are dependent on bothβ2 andα7 subunits.

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