型号:
产品价格:电议      采购度:1187      原产地:美洲
发布时间:2022/9/1 13:08:35 所属地区:国外 国外
简要描述:
α-Glucosidase-IN-18 (7B) 是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂,其 IC50 值为 μM。α-Glucosidase-IN-18 具有抗糖尿病活性。
标签:glucosidase
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MCE 站:α-Glucosidase-IN-18
产品活性:α-Glucosidase-IN-18 (7B) 是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂,其 IC50 值为 3.96 μM。α-Glucosidase-IN-18 具有抗糖尿病活性。
研究领域:Metabolic Enzyme/Protease
作用靶点:Glucosidase
In Vivo: α-Glucosidase-IN-18 (7B) (p.o., 10 or 20 mg/kg) has antidiabetic activity and significantly reduces blood glucose levels, from 392.16 mg/dL of diabetic control to 112.97 mg/dL at a concentration of 20 mg/kg after 28 days, while effectively slowing weight loss due to diabetes in male Wistar albino rats with streptozotocin-induced diabetes.
α-Glucosidase-IN-18 (7B) (p.o., 10 or 20 mg/kg) had an anti-hyperlipidemic effect with total CH levels from 226.03 mg/dL in the diabetic control to 136.4 mg/dL, LDL levels from 183.3 mg/dL to 114.18 mg/dL and TG levels from 189.35 mg/dL to 118.61 mg/dL in male Wistar albino rats with streptozotocin-induced diabetes.
α-Glucosidase-IN-18 (7B) decreases ALP levels from 3.01 mg/dL to 0.85 mg/dL and 0.79 mg/dL, SGPT levels from 59.43 mg/dL to 27.07 mg/dL and 23.91 mg/dL, SGOT levels from 49.67 mg/dL to 26.71 mg/dL and 23.08 mg/dL, serum creatinine from 3.01 mg/dL to 0.85 mg/dL and 0.79 mg/dL, and insulin levels from 0.369 mg/dL to 0.621 mg/dL and 0.639 mg/dL, respectively at doses of 10 and 20 mg/kg in male Wistar albino rats with streptozotocin-induced diabetes.
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更新时间:2024/1/2 10:26:30
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