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DAMGO TFA

CAS No. : 950492-85-0

MCE 站：DAMGO TFA

产品活性：DAMGO TFA 是一种选择性的 μ-阿片受体 (μ-OPR) 激动剂，K_d 值为 3.46 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Opioid Receptor

In Vitro: DAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt ａnd ERK1/2 by CXCL12 ａnd inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression.
DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na⁺ current (TTX-R I _Na), i.e. PGE 2 (1 μM) can increase the TTX-R I _Na peak by 103 % compared to 24.9 % with the addition of DAMGO.

In Vivo: DAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective ａnd long-lasting analgesic effect.

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