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Indole-3-pyruvic acid

CAS No. : 392-12-1

MCE 站：Indole-3-pyruvic acid

产品活性：Indole-3-pyruvic acid，色氨酸的酮类类似物，是一种具有口服活性的 AHR 激动剂。Indole-3-pyruvic acid 具有抗氧化特性，可用于炎症、焦虑的研究。

研究领域：Metabolic Enzyme/Protease  |  Immunology/Inflammation

作用靶点：Endogenous Metabolite  |  Aryl Hydrocarbon Receptor

In Vitro: Indole-3-pyruvic acid (50 ａnd 250 μM, 24 h) activates AHR in HepG2 cells.
Indole-3-pyruvic acid (50 μM, 4 days) does not inhibit Th1 cell differentiation but promotes Tr1 differentiation.
Indole-3-pyruvic acid (1 mM, 24 h) reduces UVB-induced cytotoxicity in HaCaT cells.
Indole-3-pyruvic acid (25 mM, 6 h) reduces the levels of COX-2 in HaCaT cells.

In Vivo: Indole-3-pyruvic acid (oral administration, fed in MF chow (0.1%) for 5 d) activates AHR in BALB/c mice.
Indole-3-pyruvic acid (oral administration, fed in MF chow (0.1%) for 5 wk) abrogates chronic inflammation in a T cell-mediated colitis model.
Indole-3-pyruvic acid (100 μM, dose at skin) protects against UVB-induced skin damage in HR-1 hairless mice.
Indole-3-pyruvic acid (intraperitoneal injection, 100-200 mg/kg) increases the time spent in the open arms of the elevated plus maze in mice.

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