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Antifungal agent 38

CAS No. :

MCE 站：Antifungal agent 38

产品活性：Antifungal agent 38 是一种环二硫化物，具有抗真菌和抗细菌活性。Antifungal agent 38 能诱导菌丝收缩，破坏质膜的完整性，造成细胞内容物的破坏和泄漏。

研究领域：Anti-infection

作用靶点：Bacterial  |  Fungal

In Vitro: Antifungal agent 38 (50 μg/mL) shows anti-fungal activity against 10 pathogenic fungi with inhibition rates of 56.57% (R. solani), 100% (S. sclerotiorum), 55.09% (B. cinerea), 71.23% (F. graminearum), 37.32% (M. oryzae), 50.87% (P. capsici), 100% (A. flavus), 59.75% (P. expansum), 100% (M. fructicola), 65.78% (R. stolonifer), respectively.
Antifungal agent 38 (5 μg/mL) damages plasma membrane integrity of M. fructicola.
Antifungal agent 38 (100 μg/mL) displays excellent anti-bacterial activity against X. oryzae accc 11602, X. axonpodis.
Antifungal agent 38 inhibits fungus growth with EC₅₀s of 17.09 μg/mL (R. solani), 6.34 μg/mL (S. sclerotiorum), 25.24 μg/mL (F. graminearum), >10 μg/mL (A. flavus), 10.42 μg/mL (M. fructicola), 45.71 μg/mL (B. cinerea), respectively.

In Vivo: Antifungal agent 38 (compound S8) (200 μg/mL) displays equivalent curative ａnd higher protective effects as the positive drug Thiophanate-Methyl (HY-B0842) in vivo.
Antifungal agent 38 (50, 100, 200 μg/mL, 30 mL; sprinkling) applies on pears ａnd inhibits M. fructicola growth in vivo.

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