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Trimethoprim hydrochloride

CAS No. : 60834-30-2

MCE 站：Trimethoprim hydrochloride

产品活性：Trimethoprim hydrochloride 是一种抑菌抗生素 (antibiotic)，也是一种具有口服活性的二氢叶酸还原酶 (dihydrofolate reductase) 抑制剂。Trimethoprim hydrochloride 对多种革兰氏阳性 (Gram-positive) 和革兰氏阴性需氧细菌 (Gram-negative aerobic bacteria) 具有活性。Trimethoprim hydrochloride 可用于尿路感染，志贺氏菌病和肺孢子菌肺炎的研究。Trimethoprim hydrochloride 与锌联合使用可抑制甲型流感病毒 (Influenza A virus) 对鸡胚的感染。

研究领域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：Antifolate  |  Bacterial  |  Antibiotic  |  Influenza Virus

In Vitro: Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).
Trimethoprim (3 μg/mL; 1 h) induces protein aggregation ａnd main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim sulfate presence leads to protein misfolding.
Trimethoprim (1.5-3 μg/mL; 1 h) causes induction of DnaK, DnaJ, GroEL, ClpB, ａnd IbpA/B Hsps in E. coli cells exposed to folate ａnd heat stress.

In Vivo: Trimethoprim (10 mg/kg; i.v.; once every 12 h; 3 d) shows antibacterial activity against H. influenzae, S. pneumoniae, E. coli ａnd N. meningitidis in infected mice.
Trimethoprim can be connected with the thiomaltose (TM-TMP) ａnd shows stability with a half-life of about 1 hour in complete serum, ａnd has an MIC value around 1 μM against E. coli.
Trimethoprim (10 mg/mL; 0.5 mL; inject with Trimethoprim-Zn combined suspension) decreases the virus titer ａnd increases the survival rate of chicken embryo.

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