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3＇-Sialyllactose sodium

CAS No. : 128596-80-5

MCE 站：3＇-Sialyllactose sodium

产品活性：3＇-Sialyllactose (3＇-SL) sodium 是一种益生元，具有维持免疫稳态，发挥抗炎和抗关节炎的作用。3＇-Sialyllactose sodium 是毒性等级的普通碳水化合物，可用于炎症的研究。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: 3＇-Sialyllactose sodium (0-250 μM; 24-36 h) promotes ａnd restores Col2a1 synthesis ａnd accumulates extracellular sulphated proteoglycan, ａnd inhibits the effect of inflammatory cytokines.
3＇-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 ａnd inhibits NF-κB activation in chondrocytes.
3＇-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition ａnd deposition in all strains in the presence or absence of metabolic activation.
3＇-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations ａnd shows non-clastogenic effect in either the presence or absence of metabolic activation.

In Vivo: 3＇-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis.
3＇-Sialyllactose sodium (500, 1000 ａnd 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice.
3＇-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male ａnd female beagle dogs.
3＇-Sialyllactose sodium shows a lethal dose (LD₅₀) above 20 g/kg bw, the highest dose tested.

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