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Delphinidin-3-sambubioside chloride

CAS No. : 53158-73-9

MCE 站：Delphinidin-3-sambubioside chloride

产品活性：Delphinidin-3-sambubioside (Dp3-Sam) chloride 一种具有口服活性的花青素，具有抗炎活性。Delphinidin-3-sambubioside chloride 抑制 LPS 诱导的炎症因子释放。Delphinidin-3-sambubioside chloride 还可以减轻 HFD 大鼠的肝脏脂质积累。Delphinidin-3-sambubioside (Dp3-Sam) chloride 可以从 Hibiscus sabdariffa L. 中分离出来。

研究领域：Others

作用靶点：Others

结构分类：黄酮类  |  其他黄酮类

来源：植物  |  锦葵科  |  玫瑰茄

In Vitro: Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells.
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 ａnd MEK1/2 in RAW264.7 cells.
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells.
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC₅₀ of 75 μM.
Delphinidin-3-sambubioside chloride (100-200 g/mL, 24 h) decreases intracellular TG levels ａnd lipid accumulation in oleic acid-treated HepG2 cells.

In Vivo: Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS.
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats.

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