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Glycocholic acid sodium

CAS No. : 863-57-0

MCE 站：Glycocholic acid sodium

产品活性：Glycocholic acid sodium 是具有口服活性的抗肿瘤活性的胆汁酸，可靶向作用于耐药泵和非耐药泵通路。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：萜类  |  三萜  |  结构分类

In Vitro: Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells ａnd the absorption of epirubicin in rat small intestine, ａnd intensified epirubicin-induced apoptosis. Glycocholic acid ａnd epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, ａnd MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; ａnd significantly increase the Bax-to-Bcl-2 ratio ａnd the mRNA levels of p53, caspase-9 ａnd -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp ａnd MRPs as well as regulating apoptosis-related pathways.

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