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5-OH-HxMF

CAS No. : 1176-88-1

MCE 站：5-OH-HxMF

产品活性：5-OH-HxMF 是一种羟基化的聚甲氧基黄酮，具有抗炎、抗癌、神经营养和神经保护活性。

研究领域：Apoptosis

作用靶点：Apoptosis

结构分类：黄酮类  |  黄酮  |  结构分类

来源：植物  |  芸香科  |  柑橘

In Vitro: 5-OH-HxMF (5-20 M; 48 h) effectively induces PC12 neurite outgrowth accompanied with the expression of neuronal differentiation marker protein growth-associated protein-43(GAP-43).
5-OH-HxMF (20 M; 0-120 min) causes the enhancement of cyclic AMP response element binding protein (CREB) phosphorylation, c-fos gene expression ａnd CRE-mediated transcription.
5-OH-HxMF significantly reduces the production of nitric oxide ａnd prostaglandin E2 ａnd downregulates inducible nitric oxide synthase (iNOS) ａnd COX-2 expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. 5-OH-HxMF inhibits the release of pro-inflammatory cytokines, such as tumor necrosis factor-α ａnd IL-1β, ａnd decreases the transcriptional levels. 5-OH-HxMF significantly inhibits the LPS-induced NF-κB translocation from the cytosol to the nucleus, which is associated with the abrogation of inhibitory IκBα degradation ａnd subsequent decreases in nuclear p65 levels.
5-OH-HxMF inhibits cell growth ａnd induces apoptosis in human leukemia cells.

In Vivo: 5-OH-HxMF (topically treated; twice a week; for 20 weeks; 1 ａnd 3 μmol in 200 μL acetone) is an effective antitumor agent ａnd its inhibitory effect is through the down-regulation of inflammatory iNOS ａnd COX-2 gene expression in mouse skin.

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