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α-Hydroxyglutaric acid disodium

CAS No. : 40951-21-1

MCE 站：α-Hydroxyglutaric acid disodium

产品活性：α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid disodium 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。

研究领域：Epigenetics  |  Metabolic Enzyme/Protease

作用靶点：Histone Demethylase  |  Endogenous Metabolite

结构分类：酮、醛、酸  |  结构分类

In Vitro: Isocitrate Dehydrogenase 1 (IDH1) ａnd IDH2 mutations occur frequently in gliomas ａnd acute myeloid leukemia, leading to simultaneous loss ａnd gain of activities in the production of α-ketoglutarate (α-KG) ａnd α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium, respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) disodium increases HIF-1α ａnd decreases endostatin.

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