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(±)-8-Prenylnaringenin

CAS No. : 68682-02-0

MCE 站：(±)-8-Prenylnaringenin

产品活性：(±)-8-Prenylnaringenin 是一种天然异戊二烯化类黄酮，是一种有效的植物雌激素。(±)-8-Prenylnaringenin 是一种具有口服活性的选择性雌激素受体调节剂 (SERM) (Estrogen Receptor/ERR)，可抑制 ERα 和 ERβ，IC₅₀ 分别为 57 nM 和 68 nM。(±)-8-Prenylnaringenin 具有抗癌作用，可用于骨质疏松研究。

研究领域：Vitamin D Related/Nuclear Receptor  |  Apoptosis

作用靶点：Estrogen Receptor/ERR  |  Apoptosis

In Vitro: In rabbit bone marrow cells, (±)-8-Prenylnaringenin inhibits the formation ａnd induces apoptosis of Osteoclasts to a greater extent than naringenin. (±)-8-Prenylnaringenin is applied to the MC3T3-E1 osteoblast cell line, where it enhances differentiation ａnd maturation, ａnd also inhibits the differentiation of the RAW264.7 osteoclast cell line. (±)-8-Prenylnaringenin inhibits the expression of receptor activator of nuclear factor-κB ligand (RANKL), ａnd leads to increased expression of osteoprotegerin.
A significant, dose-dependent inhibition of proliferation is observed in PC-3 human prostate cancer cells ａnd UO.31 human renal carcinoma cells after exposure to (±)-8-Prenylnaringenin. In MCF-10A, a human breast cancer cell line, (±)-8-Prenylnaringenin modulats the metabolic pathways of estradiol conversion into cancer-promoting metabolites, ａnd thereby inhibits malignant transformation.

In Vivo: (±)-8-Prenylnaringenin (50 mg/kg; orally gavage; once daily; for 12 days) ameliorates impaired glucose homeostasis ａnd islet dysfunction induced by STZ treatment. (±)-8-Prenylnaringenin increases the protein expression levels of ERα in the pancreas ａnd liver ａnd of fibroblast growth factor 21 in the liver.

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