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Me-Indoxam

CAS No. : 172732-62-6

MCE 站：Me-Indoxam

产品活性：Me-Indoxam 是一种强效且细胞不渗透的分泌磷脂酶 A₂ (sPLA₂) 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: Me-Indoxam shows different potencies on the various sPLA₂ isoforms in in vitro assays with an IC₅₀ of less than 100 nM for hGIIA, hGIIE, ａnd hGV; an IC₅₀ of between 200 ａnd 600 nM for hGIB ａnd hGX; ａnd an IC₅₀ of greater than 2 mM for hGIID, hGIIF, hGIII, ａnd hGXIIA.
Me-Indoxam is able to inhibit the activity of sPLA₂s only when they are secreted in the extracellular space.
Me-Indoxam (0-10 μM; 30 min) inhibits Leukotriene C₄ (LTC₄) production from anti-IgEstimulated primary human lung mast cells (HLMCs).
Me-indoxam (0.0110 M) did not affect the basal secretion of TNF-α ａnd IL-6 from human lung macrophages (HLM). Preincubation (15 min, 37°C) of hGX (1 μg/mL) with various concentrations of Me-indoxam before the addition to HLM dose-dependently inhibited TNF-α ａnd IL-6 release. The IC₅₀ values of Me-indoxam were 253±72 ａnd 320±87 nM on TNF-α ａnd IL-6 release, respectively.

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