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AD57

CAS No. : 1093380-42-7

MCE 站：AD57

产品活性：AD57 是一种具有口服活性的多种激酶抑制剂，抑制 RET、BRAF、S6K 和 Src 活性，但对 mTOR 的活性明显减弱。

研究领域：Protein Tyrosine Kinase/RTK  |  MAPK/ERK Pathway

作用靶点：RET  |  Raf  |  Ribosomal S6 Kinase (RSK)  |  Src

In Vitro: AD57 (0.2 nM) significantly inhibits the ptc>dRet^MEN2B lethality in the larva of Drosophila.
AD57 (0.1 nM) enhances survival of ptc>dRet^MEN2B by reducing erk gene dosage in Drosophila.

In Vivo: AD57 inhibits the viability of MEN2B (MZ-CRC-1) ａnd MEN2A (TT) patient-derived cell lines in RET^MEN2 models.
AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model.

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