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Bisindolylmaleimide I hydrochloride

CAS No. : 176504-36-2

MCE 站：Bisindolylmaleimide I hydrochloride

产品活性：Bisindolylmaleimide I (GF109203X) hydrochloride 是一种具有细胞渗透性和可逆性的 PKC 抑制剂 (对 PKCα, PKCβI, PKCβII, ａnd PKCγ 的 IC₅₀ 分别为 20 nM、17 nM、16 nM 和 20 nM)。Bisindolylmaleimide I hydrochloride 也是一种 GSK-3 抑制剂。

研究领域：Epigenetics  |  TGF-beta/Smad  |  PI3K/Akt/mTOR  |  Stem Cell/Wnt

作用靶点：PKC  |  GSK-3

In Vitro: Bisindolylmaleimide I hydrochloride (5 μM) inhibits α-thrombin-induced P47 phosphorylation.
Bisindolylmaleimide I hydrochloride (0-1 μM) inhibits DNA synthesis in quiescent swiss 3T3 cells.
Bisindolylmaleimide I hydrochloride (5 μM) reduces GSK-3 activity to 25.1±4.3% in adipocytes lysates.
Bisindolylmaleimide I hydrochloride (10 μM, 24 h) inhibits exosome ａnd microvesicle (EMV) release from PC3 cells.
Bisindolylmaleimide I hydrochloride (10 μM, 24 h) enhances cytotoxicity of 5-fluorouracil (HY-90006).

In Vivo: Bisindolylmaleimide I hydrochloride (0.02 mg/kg, i.p.) reduced the inceased NLRP3, P-PKC, ａnd PKC levels in mechanical ventilation (MV) group.
Bisindolylmaleimide I hydrochloride (0-20 mg/kg, i.p.) reduces the mean frequency of Quinpirole-induced vomiting in shrews.

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