MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

(Rac)-ZLc-002

CAS No. :

MCE 站：(Rac)-ZLc-002

产品活性：(Rac)-ZLc-002 是 nNOS 与一氧化氮合酶 1 衔接蛋白 (NOS1AP) 相互作用的抑制剂，抑制炎症性痛觉和化疗诱导的神经性疼痛，并与 Paclitaxel (HY-B0015) 协同降低肿瘤细胞活力。

研究领域：Immunology/Inflammation

作用靶点：NO Synthase

In Vitro: (Rac)-ZLc-002 (10 μM) reduces co-immunoprecipitation of NOS1AP with nNOS immunoprecipitated from primary cultured cortical neurons. (Rac)-ZLc-002 fails to disrupt nNOSNOS1AP proteinprotein interactions in the AlphaScreen in vitro binding assay. It shows no activity in a cell-free assay.
(Rac)-ZLc-002 (10 μM) reduces co-immunoprecipitation of full-length NOS1AP but not of PSD95-PDZ2 from HEK293T cells co-expressing full-length nNOS.
(Rac)-ZLc-002 (0-50 μM; 72 h) synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability.

In Vivo: (Rac)-ZLc-002 (10 mg/kg; i.p.; once or daily for 8 days) attenuates mechanical ａnd cold allodynia evoked by Paclitaxel (HY-B0015), suppresses Paclitaxel-induced neuropathic pain in a mouse model.
(Rac)-ZLc-002 (4 ａnd 10 mg/kg; i.p.; once) reduces formalin-evoked nociceptive behavior ａnd Fos-like immunoreactivity in the spinal dorsal horn in rats.
(Rac)-ZLc-002 (40 mg/kg/day; i.v.; 7 days) attenuates chronic mild stress (CMS)induced anxiogenic behavior in ICR mice.
(Rac)-ZLc-002 (10 μM; 1 μl; 30 min after Corticosterone, HY-B1618) delivering into the hippocampus for 7 days reverses the behavioural effects of glucocorticoids in mice.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Neuroprotective Compound Library  |  Angiogenesis-Related Compound Library  |  Mitochondrial Protection Compound Library  |  Membrane Protein-targeted Compound Library  |  Palmitoylglycine  |  Ermanin  |  Cistanoside A  |  Mifepristone-¹³C,d₃  |  Dehydroevodiamine hydrochloride  |  Chondroitin sulfate  |  N＇-Nitro-D-arginine  |  Banoxantrone  |  Crocin II  |  L-NIL hydrochloride  |  L-Arginine-d₇ (hydrochloride)  |  Ethyl 3,4-dihydroxybenzoate  |  2-Thiouracil-¹³C,¹⁵N₂  |  NOS-IN-3  |  3-Bromo-7-nitroindazole  |  Ethyl Caffeate  |  Beclometasone dipropionate  |  Carboxyebselen  |  (-)-10,11-Dihydroxyfarnesol  |  Cauloside C  |  Mifepristone-d₃  |  Atraric acid  |  Chloranthalactone E  |  Dimaprit dihydrochloride  |  Britannilactone diacetate  |  2-Iminobiotin  |  Inflexuside A  |  TP508  |  AVE3085  |  Dimethoxycurcumin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。