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产品价格:电议      采购度:807      原产地:美洲
发布时间:2023/4/28 13:20:57 所属地区:国外 国外
简要描述:
Anti-inflammatory agent 35 (化合物 5a27) 是一种口服有效的姜黄素类似物,具有抗炎活性。Anti-inflammatory agent 35 可阻断丝裂原活化蛋白激酶 (MAPK) 信号和 NF-kB 的核易位。Anti-inf
标签:agent
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CAS No. : 2293951-00-3
MCE 站:Anti-inflammatory agent 35
产品活性:Anti-inflammatory agent 35 (化合物 5a27) 是一种口服有效的姜黄素类似物,具有抗炎活性。Anti-inflammatory agent 35 可阻断丝裂原活化蛋白激酶 (MAPK) 信号和 NF-kB 的核易位。Anti-inflammatory agent 35 还抑制黄中性粒细胞浸润和促炎细胞因子产生。Anti-inflammatory agent 35 在体内研究中显著减轻脂多糖 (LPS) 诱导的急性肺损伤 (ALI)。
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt | NF-κB | Immunology/Inflammation | Apoptosis
作用靶点:p38 MAPK | ERK | NF-κB | Interleukin Related | TNF Receptor
In Vitro: Anti-inflammatory agent 35 (compound 5a27) (10 μM; 30 min) inhibits the production of proinflammatory cytokines (IL-6, TNF-α) induced by LPS (0.5 μg/mL; 24 h) without cytotoxicity in mouse primary macrophages (MPMs). Anti-inflammatory agent 35 inhibits the production of IL-6, TNF-α with IC50s of 2.23 μM and 2.40 μM, respectively.
Anti-inflammatory agent 35 (10 μM; 30 min) significantly inhibits LPS-induced activation in RAW 264.7 mouse macrophages. And it markedly inhibits p-p38 and p-ERK, decreases IκB level, indicating the suppression of MAPK and NF-κB signaling.
In Vivo: Anti-inflammatory agent 35 (compound 5a27) (50 mg/kg; po; single dose, monitored 0-25 min) has a better bioavailability than curcumin (HY-N0005).
Anti-inflammatory agent 35 (10 mg/kg; ip; once daily for 1 week) improves LPS-induced ALI by inhibiting inflammation in mice model.
The pharmacokinetic parameters in rats
Route | Dose (mg/kg) | AUC(0-t) (μg/Lh) | AUC(0-∞) (μg/Lh) | MRT(0-t) (h) | MRT(0-∞) (h) | t1/2 (h) | Tmax (h) | CLz/F (L/h/kg) | Vz/F (L/kg) | Cmax |
p.o | 50 | 231.2 | 325.6 | 7.8 | 12.3 | 6.7 | 3.3 | 5062.6 | 827.1 | 113.3 |
i.v | 5 | 34.3 | 122.4 | 11.3 | 19.9 | 0.2 | 0.1 | 404.4 | 59.5 | 16.4 |
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Antidepressant Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Mitochondrial Protection Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | RCGD423 | Bisabolangelone | IMD-ferulic | Karacoline | 5-Hydroxy tryptophol β-D-glucuronide-d4 | Relfovetmab | Anti-Mouse TNF alpha Antibody | LM22B-10 | Mangiferin | 4-Hydroxylonchocarpin | Vunakizumab | Insulin Detemir | Tagraxofusp | Dupilumab | Dauricine | (rac)-AG-205 | IL-17A modulator-2 | Apremilast | Poricoic acid A | Daclizumab | PNRI-299 | Ginsenoside Rg1 | GS143 | Izokibep | QNZ | 5-Aminosalicylic Acid-d3 (hydrochloride) | Lucyoside B | Sulindac | Colistin adjuvant-1 | Penehyclidine
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更新时间:2024/1/2 10:28:36
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