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3,3-Dimethyl-1-butanol

CAS No. : 624-95-3

MCE 站：3,3-Dimethyl-1-butanol

产品活性：3,3-Dimethyl-1-butanol (DMB) 是一种口服有效的三甲胺 (TMA) 和三甲基胺-N-氧化物 (TMAO) 抑制剂。3,3-Dimethyl-1-butanol 抑制 p65 NF-κB 和 TGF-β1/Smad3 信号通路。3,3-Dimethyl-1-butanol 在心血管疾病 (CVD) 中有潜在应用。

研究领域：Stem Cell/Wnt  |  TGF-beta/Smad  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：TGF-beta/Smad  |  NF-κB  |  Endogenous Metabolite

In Vitro: 3,3-Dimethyl-1-butanol is a cosurfactant of lauryl sulfobetaine/water system.

In Vivo: 3,3-Dimethyl-1-butanol (1% DMB soluble in water; p.o.; 6 weeks) significantly reduces the cardiac hypertrophy ａnd fibrosis in heart failure (HF) mice.
3,3-Dimethyl-1-butanol (0.2% ａnd 1.0% DMB soluble in water; p.o.; 21 d) increases the serum TMAO level with dose-dependent manner in ICR mice. 3,3-Dimethyl-1-butanol has been proved that the interaction between the gut ａnd the brain has a regulatory effect on social behavior.
3,3-Dimethyl-1-butanol (1.0% DMB soluble in water; p.o.; gestation period ａnd suckling period) prevents the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hypertension in offspring of pregnant Sprague-Dawley rats.

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