MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Taurodeoxycholic acid

CAS No. : 516-50-7

MCE 站：Taurodeoxycholic acid

产品活性：Taurodeoxycholic acid 是一种胆汁酸，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid 对 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 小鼠模型具有神经保护作用。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Endogenous Metabolite  |  Apoptosis

结构分类：酮、醛、酸  |  结构分类

In Vitro: Taurodeoxycholic acid (50 μM, 100 μM; 4 h) increases oligonucleosomal DNA cleavage ａnd apoptotic nuclei in primary human hepatocytes.
Taurodeoxycholic acid (400 μM; 18-24 h) increases DNA fragmentation ａnd PARP cleavage in human liver-derived cell line Huh7 cells, thus induces apoptosis.

In Vivo: Taurodeoxycholic acid (50 mg/kg; i.p.; once daliy for 34 d) prevents neuropathology ａnd associated behavioral deficits in the 3-nitropropionic acid rat model of Huntington＇s disease (HD).
Taurodeoxycholic acid (500 mg/kg; s.c.; once every 3 d for 7 weeks) leads to a significant reduction in striatal neuropathology of the R6/2 transgenic HD mouse.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Lipid Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Gut Microbial Metabolite Library  |  Microbial Metabolite Library  |  Neurodegenerative Disease-related Compound Library  |  Food-Sourced Compound Library   |  Human Metabolite Library  |  Off-patent Drug Library  |  D-Valine-d₈  |  SY-5609  |  D-α-Hydroxyglutaric acid disodium  |  BRD4 Inhibitor-18  |  Nicotinamide N-oxide  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  Deoxycholic acid-d₅  |  Doxorubicin-¹³C,d₃ (TFA)  |  Palitantin  |  Estradiol hemihydrate  |  AAPK-25  |  Dutasteride-¹³C₆  |  Adrenaline sulfate  |  Oleic acid-¹³C  |  Dextranase  |  H2S Donor 5a  |  Abacavir sulfate  |  Methylmalonic acid  |  Meloxicam-d₃-1  |  Glycine, N-(aminoiminomethyl)-N-methyl-¹³C  |  Dihydroxyacetone phosphate  |  Thailanstatin D  |  SB-218078  |  Toyocamycin  |  Sorafenib-d₄  |  Sphingomyelin  |  (-)-Jasmonoyl-L-isoleucine  |  Busulfan  |  PTC-028  |  Dinaciclib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。