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(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH

CAS No. : 52435-06-0

MCE 站：(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH

产品活性：(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon，Mwt 1167.34 Da) 是一种促性腺激素释放激素 (GnRH) 激动剂。(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH 能作为醋酸亮丙瑞林 LC-MS 分析的内标。(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH 在生化分析和生育中有潜在应用。

研究领域：GPCR/G Protein

作用靶点：GnRH Receptor

In Vitro: (Des-Gly10, D-Ala6, Pro-NHEt9)-LHRH as internal standard for leuprorelin acetate
(1) Add 10 μL 200 ng/mL (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH solution to 100 μL plasma sample.
(2) Add ice-cold acetonitrile to solution in (1) in two batches (500 L each time).
(3) Stir at 2500 rpm for 10 min.
(4) Centrifugation at 12500 rpm (4℃) for 10min.
(5) Transfer the supernatant into a centrifuge tube, dried under nitrogen gas at 35℃, ａnd finally add 100 L 0.1% formic acid in water/acetonitrile: 90/10 (v/v) solution.
(6) The Thermo Scientific Vanquish UPLC system is connected to the Thermo Scientific Orbitrap Explorer 480 mass spectrometer. Using the Waters Acquity UPLC HSS T3 column (2.1 × 100 mm, 1.8 m) separation at a temperature of 40℃.
(7) The mobile phase A is 0.1% formic acid in water, ａnd the mobile phase B is 0.1% formic acid in acetonitrile solution. The gradient starts at 95% mobile phase A, decreases to 10% over 5 min, ａnd then remains constant for 0.5 min. At 6 min, the column returned to 95% mobile phase A ａnd is rebalanced for 2 min. The flow rate was 0.3 mL/min ａnd the injection volume is 20 L.
(8) The sample is ionized by 3500V electric spray. In positive-ion mode, m/z 605.3275 is leuprolide acetate, ａnd m/z 584.3052 is the internal standard. Data are analyzed by Xcalibur software (version 4.4).

In Vivo: (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 g/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with ａnd without gonadectomy.
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 g; single dose) improves the fertility of cows after fertilization ａnd prevents embryo death when combined with Ainil (30 L/kg).

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