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Retinoic acid-d₅

CAS No. : 78996-15-3

MCE 站：Retinoic acid-d₅

产品活性：Retinoic acid-d₅ 是氘标记的视黄酸 (HY-14649)。Retinoic acid 是维生素 A 的代谢产物，在细胞生长、分化和器官发生中起重要作用。Retinoic acid 是 RAR 核受体的天然激动剂，对 RARα/β/γ 的 IC₅₀ 为 14 nM。Retinoic acid 与 PPARβ/δ 结合，K_d 为 17 nM。Retinoic acid 通过激活 Retinoic acid 受体 α 作为转录因子 Nrf2 的抑制剂。

研究领域：Others  |  Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor  |  Cell Cycle/DNA Damage

作用靶点：Isotope-Labeled Compounds  |  RAR/RXR  |  PPAR

In Vitro: Stable heavy isotopes of hydrogen, carbon, ａnd other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic ａnd metabolic profiles of drugs.
Retinoic acid (All-trans-retinoic acid, ATRA) is a highly potent derivative of vitamin A that is required for virtually all essential physiological processes ａnd functions because of its involvement in transcriptional regulation of over 530 different genes. Retinoic acid exerts its actions by serving as an activating ligand of nuclear retinoic acid receptors (RARα-γ), which form heterodimers with retinoid X receptors (RXRα-γ).
Retinoic acid (RA) bound to PPARα ａnd PPARγ with a low affinity demonstrated by K_d values of 100-200 nM. In contrast, Retinoic acid associates with PPARβ/δ with a K_d of 17 nM, revealing both high affinity ａnd isotype selectivity.
Undifferentiated P19 cells express the Retinoic acid (RA) receptors RARα, RARβ, RARγ, ａnd PPARβ/δ, as well as the Retinoic acid -binding proteins CRABP-II ａnd FABP5. Induction of differentiation by treatment of cells with Retinoic acid results in transient up-regulation of CRABP-II ａnd down-regulation of FABP5 that are observed at the level of both the respective proteins ａnd mRNAs. Following the initial decrease, the level of both FABP5 protein ａnd mRNA increases to attain a 2-2.5-fold higher level in mature neurons as compared with undifferentiated P19 cells. Induction of differentiation does not markedly affect the levels of either RARα or PPARβ/δ. The level of RARγ mRNA decreases by about 5-fold by day 4 ａnd remained low in mature neurons.
Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles in cell growth, differentiation, ａnd organogenesis. The Retinoic acid interacts with retinoic acid receptor (RAR) ａnd retinoic acid X receptor (RXR) which then regulate the target gene expression.

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