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Chenodeoxycholic acid sodium

CAS No. : 2646-38-0

MCE 站：Chenodeoxycholic acid sodium

产品活性：Chenodeoxycholic acid sodium 是一种疏水初级胆汁酸，能够活化核受体 FXR，该受体与胆固醇代谢有关。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：FXR  |  Autophagy  |  Endogenous Metabolite

In Vitro: Chenodeoxycholic acid sodium (CDCA) ａnd Deoxycholic acid (DCA) both inhibit 11 beta HSD2 with IC₅₀ values of 22 mM ａnd 38 mM, respectively ａnd causes cortisol-dependent nuclear translocation ａnd increases transcriptionalactivity of mineralocorticoid receptor (MR). Chenodeoxycholic acid sodium is able to stimulate Ishikawa cell growth by inducing a significant increase in Cyclin D1 protein ａnd mRNA expression through the activation of the membrane G protein-coupled receptor (TGR5)-dependent pathway. Chenodeoxycholic acid sodium (CDCA) induces LDL receptor mRNA levels approximately 4 fold ａnd mRNA levels for HMG-CoA reductase ａnd HMG-CoA synthase two fold in a cultured human hepatoblastoma cell line, Hep G2. Chenodeoxycholic acid sodium-induced Isc is inhibited (≥67%) by Bumetanide, BaCl₂, ａnd the cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor CFTRinh-172. Chenodeoxycholic acid sodium-stimulated Isc is decreased 43% by the adenylate cyclase inhibitor MDL12330A ａnd Chenodeoxycholic acid sodium increases intracellular cAMP concentration. Chenodeoxycholic acid sodium treatment activates C/EBPβ, as shown by increases in its phosphorylation, nuclear accumulation, ａnd expression in HepG2 cells. Chenodeoxycholic acid sodium enhances luciferase gene transcription from the construct containing -1.65-kb GSTA2 promoter, which contains C/EBP response element (pGL-1651). Chenodeoxycholic acid sodium treatment activates AMP-activated protein kinase (AMPK), which leads to extracellular signal-regulated kinase 1/2 (ERK1/2) activation, as evidenced by the results of experiments using a dominant-negative mutant of AMPKα ａnd chemical inhibitor.

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