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ACVR2A/Activin RIIA Protein, Human (HEK293, C-His)

MCE 站：ACVR2A/Activin RIIA Protein, Human (HEK293, C-His)

ACVR2A，也称为激活素 RIIA，是一种激活素 II 型受体。在配体结合时，ACVR2A 可以形成由两种 II 型和两种 I 型跨膜丝氨酸/苏氨酸激酶组成的受体复合物。ACVR2A 是 Activin A、Activin B 和 Inhibin A 的受体。ACVR2A/Activin RIIA Protein, Human (HEK293, His) 在 HEK293 细胞中产生，由 115 个氨基酸 (A20-P134) 组成，在 C 末端带有六个 His 标签。

Synonyms: rHuActivin receptor type 2A, His; ACVR-2A; Activin receptor type 2A

Species: Human

Source: HEK293

Biological Activity: Measured by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The ED₅₀ this effect is 0.0487 μg/ml in the presence of 7.5 ng/mL Activin A, corresponding to a specific activity is 2.05×10^4 units/mg.

研究背景：ACVR2A is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2A is a receptor for Activin A, Activin B ａnd Inhibin A.
The sequence of amino acids in ACVR2A proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ACVR2A has been only slightly altered, ａnd that both in humans ａnd in animals, its function is similar.
Signaling by activins ａnd BMPs is highly promiscuous, since apart from signaling through ALK4/7, the activin type II receptors (ACVR2A ａnd 2B) can interact also with several type I BMP receptors (ALK1/2/3/6), which can also form complexes with the type II BMP receptor, BMPRII. Type II receptors phosphorylate ａnd activate type I receptors which autophosphorylate, then bind ａnd activate SMAD transcriptional regulators. ACVR2A can form complexes with different type I receptors that signal either to Smad2/3 (ALK4) or to Smad1/5/8 (ALK2, ALK3, ALK6). The different type I receptors compete for binding to ACVR2A ａnd that this competition provides a mechanism that balances signaling between Activin A-mediated, ALK4-dependent Smad2/3 signaling, ａnd BMP-mediated ALK2 or ALK3-dependent signaling to Smad1/5/8. In myeloma cells, BMP-6- ａnd BMP-9-induced activation of SMAD1/5/8 through ACVR2A/ACVR2B/ALK2 is inhibited by activin A treatment.

蛋白编号：P27037 (A20-P134)

基因 ID：92

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