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产品价格:电议      采购度:812      原产地:美洲
发布时间:2023/7/28 16:43:14 所属地区:国外 国外
简要描述:
Merolol succinate 是一种具有口服活性的、选择性的 β1-肾上腺素受体 (β1-adrenoceptor) 拮抗剂。Merolol succinate 具有抗炎、抗肿瘤和抗血管生成的特性。
标签:Toprol
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CAS No. : 98418-47-4
MCE 站:Metoprolol succinate
产品活性:Metoprolol succinate 是一种具有口服活性的、选择性的 β1-肾上腺素受体 (β1-adrenoceptor) 拮抗剂。Metoprolol succinate 具有抗炎、抗肿瘤和抗血管生成的特性。
研究领域:GPCR/G Protein | Neuronal Signaling | Apoptosis
作用靶点:Adrenergic Receptor | Apoptosis
In Vitro: Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 and MOLT-4 cells dose and time dependently.
In Vivo: Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines and atherosclerosis in ApoE/ Mice.
Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation and anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis.
Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats.
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更新时间:2024/1/2 10:31:08
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