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SH-4-54

CAS No. : 1456632-40-8

MCE 站：SH-4-54

产品活性：SH-4-54是 STAT 的抑制剂，与 STAT3 和 STAT5 结合的 K_Ds 值分别为300，464 nM。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶点：STAT

In Vitro: SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) ａnd effectively suppresses STAT3 phosphorylation ａnd its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC₅₀s, inhibiting STAT3＇s downstream targets, ａnd shows no discernible off-target effects at therapeutic doses.

In Vivo: SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, ａnd inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs ａnd validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation ａnd increase apoptosis of treated tumors.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Obesity Compound Library  |  Transcription Factor-Targeted Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Cancer Stem Cells Compound Library  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  Stafia-1-dipivaloyloxymethyl ester  |  Niclosamide monohydrate  |  Brevilin A  |  STAT3 degrader-1  |  NSC-370284  |  Broussonin E  |  RO8191  |  Eflepedocokin alfa  |  Morusin  |  STAT3-IN-13  |  Antitumor agent-73  |  1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea  |  IST5-002  |  Delphinidin chloride  |  SC-43  |  Astaxanthin  |  LLL12  |  MNK8  |  Syk-IN-6  |  STAT5-IN-2  |  (+)-Ochromyci  |  STAT3-IN-11  |  HP590  |  FLLL32  |  SI-109  |  Stafib-2  |  SD-1029  |  Colivelin

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