MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BAY-549

CAS No. : 867017-68-3

MCE 站：BAY-549

产品活性：BAY-549 (Azaindole 1) 是有口服活性，ATP-竞争型的 ROCK 抑制剂，对 ROCK-1 和 ROCK-2 的 IC₅₀ 值分别为 0.6 和 1.1 nM。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Cytoskeleton  |  TGF-beta/Smad

作用靶点：ROCK

In Vitro: BAY-549 (Azaindole 1) is a highly potent inhibitor of human ROCK-1 ａnd ROCK-2, with IC₅₀s of 0.6 ａnd 1.1nM, respectively, ａnd also inhibits murine ROCK-2 or rat ROCK-2 with IC₅₀s of 2.4 ａnd 0.8nM, respectively. BAY-549 also inhibits receptor tyrosine kinases TRK ａnd FLT3, with IC₅₀s of 252 ａnd 303nM, respectively, but shows slight inhibition of MLCK ａnd ZIP-kinase with IC₅₀s of 7.4μM ａnd 4.1μM, respectively. BAY-549 induces vasorelaxation in vitro, ａnd suppresses the phenylephrine-induced contraction of rabbit saphenous artery in a concentration dependent manner with an IC₅₀ value of 65nM.

In Vivo: BAY-549 (Azaindole 1) (0.03, 0.1, 0.3mg/kg, i.v.) results in a dose-dependent ａnd long-lasting decrease in blood pressure in anaesthetized normotensive rats. BAY-549 (3 ａnd 10mg/kg, p.o.) decreases blood pressure dose-dependently ａnd persistently both in normotensive ａnd hypertensive rats, ａnd shows such effects even at 1mg/kg in hypertensive rats. BAY-549 (0.1 ａnd 0.3mg/kg, i.v. bolus injections) causes decreased mean arterial blood pressure in a dose-related manner ａnd only leads to a moderate ａnd dose-independent increase in heart rate of anaesthetized dogs.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Chemical Probe Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Serine/Threonine Kinase Inhibitor Library  |  Chroman 1 dihydrochloride  |  Ripasudil free base  |  AS1892802  |  Hu7691 free base  |  CaMKP inhibitor sodium  |  ROCK2-IN-6  |  Sovesudil  |  AT13148  |  CRT0066854  |  ROCK-IN-9  |  LX7101  |  Y-27632 dihydrochloride  |  RKI-1447  |  HA-100 hydrochloride  |  WF-536  |  ROCK-IN-6  |  Pentanoic acid-d₉  |  LIMK-IN-1  |  Fasudil dihydrochloride  |  ROCK-IN-5  |  ROCK2-IN-5  |  BDP5290  |  PF-4950834  |  PT-262  |  Afuresertib hydrochloride  |  Belumosudil mesylate  |  GSK429286A

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。