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SRT 1720 monohydrochloride

CAS No. : 2060259-60-9

MCE 站：SRT 1720 monohydrochloride

产品活性：SRT 1720 monohydrochloride 是选择性的和具有口服活性的 SIRT1 激活剂，EC₅₀为 0.10 μM，对 SIRT2 和 SIRT3 的作用较弱。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy

作用靶点：Sirtuin  |  Autophagy

In Vitro: SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, ａnd this is attributed to inhibition of histone acetyltransferase p300.

In Vivo: SRT 1720 (10, 30, 100 mg/kg, p.o.) treatment significantly reduces fasting blood glucose to near normal levels in Lep^ob/ob mice.
SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, ａnd has a connection to metabolic adaptation in fatty acid ａnd oxidative metabolism.
SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement ａnd lung function impairment as well as reduces arterial oxygen saturation in WT mice.

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