MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PF-670462 dihydrochloride

CAS No. : 950912-80-8

MCE 站：PF-670462 dihydrochloride

产品活性：PF-670462 dihydrochloride 是一种有效的，选择性的 casein kinase (CKIε/CKIδ) 抑制剂，IC₅₀ 值分别为 7.7 nM 和 14 nM。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt

作用靶点：Casein Kinase

In Vitro: PF-670462 is a potent ａnd selective inhibitor of CKIε ａnd CKIδ, with IC₅₀s of 7.7 nM ａnd 14 nM, respectively. PF-670462 shows less than 30-fold selevtivity for EGFR ａnd SAPK2A/p38, with IC₅₀s of 150 nM ａnd 190 nM, respectively. PF-670462 also causes a redistribution of the GFP signal to the cytoplasm in a concentration-dependent manner, with an EC₅₀ of 290 ± 39 nM in CKIε-transfected COS7 cells. PF-670462 is a potent inhibitor of Wnt/β-catenin signaling, with an IC₅₀ of 17nM. PF-670462 (1μM) is a weak inhibitor of proliferation, ａnd only modestly suppresses the growth of HEK293 ａnd HT1080 cells. PF-670462 (100 nM) strongly inhibits CK1ε ａnd CK1δ, consistent with its effect on Wnt/β-catenin signaling.

In Vivo: PF-670462 (50 mg/kg, s.c.) produces robust phase delays, ａnd the activity remains persistent, with no discernible correction in the absence of exogenous zeitgebers in rats. PF-670462 (25, 50, ａnd 100 mg/kg, s.c.) induces dose-dependent phase shift. PF-670462 (50 mg/kg; s.c.) significantly phase delays the rhythmic transcription of Bmal1, Per1, Per2 ａnd Nr1d1 in both liver ａnd pancreas by 4.5 ± 1.3 h ａnd 4.5 ± 1.2 h, respectively, 1 day after administration. In the suprachiasmatic nucleus (SCN), the rhythm of Nr1d1 ａnd Dbp mRNA expression is also delayed by 4.2 ａnd 4 h, respectively.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Cancer Stem Cells Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  CK2-IN-4  |  Umbralisib hydrochloride  |  Casein kinase 1δ-IN-5  |  4,5,6,7-Tetrabromo-1H-benzimidazole  |  JNJ-6204  |  CK2-IN-1  |  PF-5006739  |  TA-01  |  Ellagic acid  |  EGFR-IN-57  |  AMG-548 hydrochloride  |  CKI-7 free base  |  SR-1277  |  CK2α-IN-1  |  NCC007  |  Emodin-d₄  |  Casein Kinase II Inhibitor IV  |  TMX-4113  |  BTX161  |  D4476  |  Casein Kinase II Receptor Peptide  |  PI-828  |  TBCA  |  CK2 inhibitor 2  |  TTP 22  |  Longdaysin  |  CK2/ERK8-IN-1  |  TMCB

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。