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Zenidolol hydrochloride

CAS No. : 72795-01-8

MCE 站：Zenidolol hydrochloride

产品活性：Zenidolol (ICI-118551) hydrochloride 是一种高度选择性的 β2 adrenergic receptor 拮抗剂，结合 β2，β1 和 β3 肾上腺素能受体的K_i 值分别为 0.7，49.5 和 611 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Zenidolol (ICI-118551) hydrochloride inhibits cAMP accumulation with IC₅₀ of 1.7 μM in IMCD cells.
Zenidolol (ICI-118551; 10 μM) hydrochloride induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO.
In failing human heart, Zenidolol (ICI-118551) hydrochloride has significant effects on beat duration, with time-to-peak contraction ａnd time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of Zenidolol (ICI-118551) hydrochloride Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of Zenidolol (ICI-118551) hydrochloride.

In Vivo: Zenidolol (ICI-118551; 0.2 mg/kg) hydrochloride injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.

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