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Ecopipam hydrochloride

CAS No. : 190133-94-9

MCE 站：Ecopipam hydrochloride

产品活性：Ecopipam (SCH 39166) hydrochloride 是一种有效的、选择性、具有口服活性的多巴胺 D1/D5 受体拮抗剂，K_i 值分别为 1.2 nM 和 2.0 nM。Ecopipam hydrochloride 对 D2、D4、5-HT 和 α2a 受体 (K_i=0.98，5.52，0.08 和 0.73 μM) 显示出超过 40 倍的选择性。Ecopipam hydrochloride 可用于精神分裂症和肥胖症的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor  |  5-HT Receptor  |  Adrenergic Receptor

In Vitro: Ecopipam (2 μM) hydrochloride completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation.

In Vivo: Ecopipam (0.003-0.3 mg/kg, a single s.c.) hydrochloride abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats.
Ecopipam (10, mg/kg, oral administration) hydrochloride antagonizes Apomorphine-induced stereotypy in rats.
Ecopipam (5 ａnd 10 μM, perfusion, 1 μL/min) hydrochloride reversibly ａnd dose-dependently decreases acetylcholine release in the rat striatum.

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