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Larsucosterol (trimethylamine)

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MCE 站：Larsucosterol (trimethylamine)

产品活性：Larsucosterol (DUR-928) trimethylamine 是一种胆固醇代谢物，是一种有效的肝 X 受体 (LXR) 拮抗剂。Larsucosterol trimethylamine 是一种有效的内源性脂肪生成调节剂。Larsucosterol trimethylamine 通过降低 mRNA 水平和抑制 SREBP-1 的激活抑制胆固醇的生物合成。

研究领域：Vitamin D Related/Nuclear Receptor  |  Metabolic Enzyme/Protease

作用靶点：LXR  |  Endogenous Metabolite

In Vitro: Larsucosterol (DUR-928; 0-25 μM; 8 h; HepG2 cells) trimethylamine inhibits cholesterol biosynthesis by decreasing HMG-CoA reductase mRNA levels ａnd decreases free [¹⁴C] cholesterol in a dose-dependent manner.
Larsucosterol (0-25 μM; 6 h; HepG2 cells) trimethylamine inhibits HMG-CoA reductase expression by inhibition of both SREBP1 activation ａnd expression in hepatocytes.
Larsucosterol (0-50 μM; 48 h) trimethylamine increases cell proliferation ａnd decreases apoptosis in macrophages.
Larsucosterol (0-25 μM; 48 h; macrophages) trimethylamine inhibits activation of liver oxysterol receptor LXRα.

In Vivo: Larsucosterol (DUR-928; 25 mg/kg; i.p.; twice in 14 hours; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) trimethylamine reduces serum lipid levels in mice fed a high-fat diet.
Larsucosterol (25 mg/kg; i.p.; twice in 14 hours; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) trimethylamine suppressed the expression of the genes ａnd inhibits ABCA1 expressionde. Larsucosterolcreases nuclear SREBP-1 Protein levels ａnd cytoplasmic FAS ａnd ACC1 protein levels in liver tissue.
Larsucosterol (25 mg/kg; i.p.; once every 3 days for 6 weeks; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) trimethylamine protects the liver from injury by suppressing hepatic inflammation.

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