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Nefazodone

CAS No. : 83366-66-9

MCE 站：Nefazodone

产品活性：Nefazodone 是一种具有口服活性的苯基哌嗪类抗抑郁剂。Nefazodone 可有效、选择性地阻断突触后 5-HT_2A 受体，适度抑制 5-HT 和去甲肾上腺素 (noradrenaline) 再摄取。Nefazodone 还可以缓解应激反应对小鼠免疫系统的不良影响。Nefazodone 对 CYP3A4 同工酶具有较高的亲和力，表明其存在一定的活性分子-活性分子相互作用风险。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：5-HT Receptor  |  Cytochrome P450

In Vitro: Nefazodone collapses mitochondrial membrane potential, ａnd imposes oxidative stress, as detected via glutathione depletion, leading to cell death.
Nefazodone (200 μM; 24 h) depletes 100% of ATP in both, glucose ａnd galactose-grown HepG2 cells.
Nefazodone (6.25, 12.5 ａnd 25 μM; 0-120 min) profoundly inhibits oxygen consumption (OCR) in HepG2.

In Vivo: Nefazodone (10 mg/kg; s.c.; for 16 days) is effective to counter the adverse effects of stress on the the immune system of mice.

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