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Fexofenadine

CAS No. : 83799-24-0

MCE 站：Fexofenadine

产品活性：Fexofenadine (MDL-16455) 是一种具有口服活性和非镇静性的 H₁ 受体拮抗剂。Fexofenadine 可用于过敏性鼻炎和慢性特发性荨麻疹的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Fexofenadine (1-100 M; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.
Fexofenadine (1-100 M; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.

In Vivo: Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia ａnd systemic anaphylaxis in C57BL/6 mice infected with T. spiralis.

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