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Tranylcypromine hydrochloride

CAS No. : 1986-47-6

MCE 站：Tranylcypromine hydrochloride

产品活性：Tranylcypromine hydrochloride (SKF 385 hydrochloride) 是 lysine-specific demethylase 1 (LSD1/BHC110) 和 monoamine oxidase (MAO) 的不可逆抑制剂。Tranylcypromine hydrochloride 抑制 LSD1，MAO A 和 MAO B 的 IC₅₀ 值分别为 20.7，2.3 和 0.95 μM。Tranylcypromine hydrochloride 可用于忧郁症的研究。

研究领域：Neuronal Signaling

作用靶点：Monoamine Oxidase

In Vitro: Tranylcypromine hydrochlorid (50 μM-5 mM; 1 h or 12-14 h) inhibits histone ａnd nucleosomal demethylation.
Tranylcypromine hydrochlorid (2 μM; 3 h) shows a specific derepression of OCT4 transcription.
Tranylcypromine hydrochlorid (0-100 μM; 15 min) shows IC₅₀ values of 20.7, 2.3 ａnd 0.95 μM for LSD1, MAO A ａnd MAO B, respectively.
Tranylcypromine hydrochlorid (0-800 μM) shows K_i values of 242.7, 101.9 ａnd 16 μM for LSD1, MAO A ａnd MAO B, respectively.

In Vivo: Tranylcypromine hydrochlorid (3 mg/kg; i.p. once daily for 3 days) decreases LPS-mediated microglial activation ａnd proinflammatory cytokine COX-2 ａnd IL-6 levels in wild-type mice.
Tranylcypromine hydrochlorid (3 mg/kg; i.p. once daily for 7 days) down-regulates Aβ-mediate microglial activation in 5xFAD mice.

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