MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

M62812

CAS No. : 613263-00-6

MCE 站：M62812

产品活性：M62812 是一种 toll 样受体 4 (TLR4) 信号转导抑制剂。M62812 可抑制内皮细胞和白细胞活化，防止小鼠发生致死性感染性休克。M62812 可以降低 LPS 诱导的凝血反应和炎症反应。M62812 可用于脓毒症的研究。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: M62812 (10 μg/mL; 6 h) completely inhibits LPS-induced NF-κB activation in NF-κB luciferase-expressing cells with an IC₅₀ of 2.4 μg/mL.
M62812 (3 μg/mL; 6 h) completely inhibits LPS-induced TNF-α production in peripheral blood mononuclear cells with an IC₅₀ of 0.7 μg/mL.
M62812 (3 μg/mL; 6 h) completely inhibits the production of IL-6 ａnd E-selection in human endothelial cells with IC₅₀s of 0.43 μg/mL ａnd 1.4 μg/mL.

In Vivo: M62812 (i.v.; 10-20 mg/kg; single dose) is protective ａnd reduces inflammatory ａnd coagulation parameters in a D-galactosamine-sensitized endotoxin shock mouse model.
M62812 (i.v.; 20 mg/kg; once a day for three days) prevents mice from lethality in a murine cecal ligation ａnd puncture model.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Immunology/Inflammation Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Antioxidant Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Coagulation ａnd Anti-coagulation Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Autoimmune Disease Compound Library  |  C29  |  ODN 1018  |  TLR7 agonist 5  |  Biotin-labeled ODN 2395  |  AN-3485  |  ODN 2088  |  TLR4/NF-κB/MAPK-IN-1  |  FITC-labeled ODN TTAGGG  |  Guretolimod hydrochloride  |  TLR9-IN-1  |  Complete Freund＇s adjuvant (CFA)  |  TLR8 agonist 6  |  ODN 105871  |  MC-Val-Cit-PAB-Amide-TLR7 agonist 4  |  Monophosphoryl lipid A  |  FITC-labeled ODN 2216  |  β-D-Glucan  |  Poly (I:C):Kanamycin (1:1) (sodium)  |  Bropirimine  |  Polygalasaponin F  |  Chloroquine-d₅ diphosphate  |  DB-3-291  |  ODN 24888  |  Hydroxychloroquine sulfate (Standard)  |  Agatolimod  |  Enpatoran hydrochloride  |  BBIQ  |  UC-1V150

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。