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TGF beta 1/TGFB1 Protein, Human (CHO)

MCE 站：TGF beta 1/TGFB1 Protein, Human (CHO)

TGF beta 1/TGFB1 蛋白*初被认为是一种诱导啮齿动物成纤维细胞生长的生长因子。TGF beta 1/TGFB1 蛋白可将细胞阻滞在 G1 期。TGF beta 1/TGFB1 是内源性调节细胞凋亡的因子。重组人 TGF beta 1/TGFB1 蛋白 是由 CHO 细胞表达的，A279-S390 片段的蛋白。

Synonyms: TGF-beta-1; TGFB1; TGFB; rHuTGF-β1

Species: Human

Source: CHO

Biological Activity: 1. The ED₅₀ is <0.2 ng/mL as measured in ability to inhibit the mouse IL-4-dependent proliferation of HT-2 cells.
2. The ability to inhibit the IL-4-dependent proliferation of TF 1 human erythroleukemic cells has an ED₅₀ value of 4-40 pg/mL.

研究背景：TGF beta 1/TGFB1 Protein (transforming growth factor beta 1) is a multifunctional cytokine, which is synthesized by almost all cells. TGF beta 1/TGFB1 Protein has a high ability to bind with TGFbRII.
The sequence of amino acids in TGFb1 proteins from different species is very stable, which leads to the conclusion that in the process of evolution, TGFb has been only slightly altered, ａnd that both in humans ａnd in animals, its function is similar.TGF beta 1/TGFB1 Protein is secreted as an inactive peptide, forming part of a ‘latent complex’ consisting of a mature TGFB1 dimer non-covalently bound to its latency-associated peptide (LAP) and, via LAP, to latent TGFB-binding proteins (LTBPs). Activated TGF beta 1/TGFB1 Protein binds to ubiquitously expressed cell-surface TGFB1 type I receptors (TGFBRI) ａnd type II receptors (TGFBRII), which are transmembrane serine/threonine kinases.
TGF beta 1/TGFB1 Protein regulates cell proliferation, growth, differentiation ａnd cells movement. TGFb1 has immunomodulatory effects. TGF beta 1/TGFB1 Protein has profibrogenic effects. TGF beta 1/TGFB1 Protein action can be local ａnd systemic. TGF beta 1/TGFB1 Protein plays a driving role in development, fibrosis ａnd cancer.

蛋白编号：P01137 (A279-S390)

基因 ID：7040

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  转化生长因子β  |  转化生长因子-β1  |  细胞因子和生长因子  |  神经营养因子  |  转化生长因子-β  |  转化生长因子-β1

Categories：Cytokines ａnd Growth Factors  |  TGF-beta Superfamily  |  Transforming Growth Factor-β  |  TGF-β1  |  Cytokines ａnd Growth Factors  |  Neurotrophic Factors  |  TGF- β  |  TGF-β1

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